But it can also be pretty intimidating for first timers, which is why we tapped experts for their advice on how to get started—and how to get the most out of it. Here's what they have to say. For starters, the anal region is rich in sensitive nerve endings that can make it a pleasure gold mine. And since the tissue between the rectum and vagina is so thin, sometimes anal pressure stimulates the front wall of the vagina, where the G-spot is. That makes it a surprisingly effective way to get that elusive G-spot stimulation.